. "AIIMS aur IARC Experts Kehta Hai: Smoking Impact Cancer Trials Pe"

                                                     

Cancer Trials and Smoking: Who Are the Experts?

Experts from AIIMS Delhi, McMaster University (Canada), and IARC (France) have issued an important warning: "Cancer clinical trials me smoking status record karna bahut zaruri hai." Agar patients smoking continue karte hain, toh treatment ki efficacy aur survival par negative impact pad sakta hai.

🔹 Research Ka Main Point

Lancet Oncology me publish commentary ke hisaab se, smoking status jaanna doctors ke liye important hai. Agar patient smoking kar raha hai, toh therapy aur treatment decisions accordingly adjust kiye ja sakte hain. 2014 ke US Surgeon General report me pehli baar smoking aur cancer mortality ke beech causal link establish hua. Isliye, systematic tobacco data capture in clinical trials is essential. ✅

⚡ Smoking Se Treatment Kaise Effect Hota Hai?

• Systemic therapy, surgery aur radiotherapy ke outcomes tobacco use se negatively affect hote hain.
• Mechanisms: Tumour hypoxia, altered drug metabolism, nicotine signalling pathways, aur immune system changes (NK cells kam hona) 🔬
• Erlotinib dose doubling example: Jo patients smoking continue karte hain unko 150 mg se 300 mg daily chahiye taaki therapeutic concentration achieve ho.

✅ Quit Karna Kitna Important Hai

Meta-analyses demonstrate karte hain ki diagnosis ke baad smoking quit karna patient ki survival ko improve karta hai. Early quitting ka benefit sabse zyada hai — kabhi-kabhi therapy se bhi zyada impact padta hai. 💚

⚠️ Trials Me Data Capture Ki Challenges

• Standardized tools aur protocols ki kami se data inconsistent hota hai.
• Clinicians aur researchers perceive karte hain ki tobacco use ka impact minimal hai, isliye data miss ho jata hai.
• Time aur resources limited, electronic health record templates missing, aur automated prompts absent.
• Pharma companies ko lag sakta hai ki smoking status track karna drug approval ya market size ke liye risk ho sakta hai.

🌿 Intervention & Cessation

2024 ke study ke hisaab se, cessation support diagnosis ke 6 months ke andar provide karna sabse effective hai. E-cigarettes bhi capture karni chahiye trials me, lekin unka impact active smoking se kam hai. Canada, Australia, aur US ke cancer centres me patient registration ke time smoking cessation discuss karna standard practice ban gaya hai. IASLC 2023 ne bhi declare kiya hai ki smoking status capture clinical trials me essential hai.

📌 Bottom Line

Experts conclude karte hain: "Capturing smoking status in clinical trials should no longer be considered optional; it should be regarded as an essential core element of cancer research." Treatment effectiveness aur patient survival ke liye ye data capture karna bahut zaruri hai. 🩺